1.Isotretinoin: highly teratogenic, can cause central nervous system malformations, heart, thymus, eye and other organ malformations; 2.Misoprostol: can cause congenital malformations, sixth cerebral nerve palsy, miscarriage, etc.; 3.Methotrexate: in the early stages of pregnancy caused by the high rate of miscarriage, but also can lead to craniofacial or skeletal defects; 4.Warfarin: can cause warfarin embryopathy, resulting in intrauterine growth restriction, nasal bone 5.Ergotamine: can cause congenital malformations, uterine contractions; 6.Angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor antagonists: can cause fetal cranial dysplasia, renal failure, low amniotic fluid and even fetal death; 7.Nitroprusside: can cause the risk of fetal cyanide poisoning; 8.Quinolone: can cause arthrosis in children; 9.Tetracyclines : closely integrated with calcium during bone and tooth development; causes changes in bone and tooth color after 20 weeks of gestation; 10, anti-epileptic drugs: all long-term application of anti-epileptic drugs (AED) can cause similar malformations (orofacial cleft, congenital heart disease, open neural tube malformation, etc.); 11, streptomycin, kanamycin: can cause neurological deafness; 12, ketoconazole (systemic drugs): Current systemic treatment can affect the genital development of male fetuses; 13. Amiodarone: long-term application of amiodarone by the mother has the potential risk of causing thyroid dysfunction or goiter in the newborn, and this risk is related to the dose and duration of the mother’s medication; 14. Other: cyclophosphamide, tamoxifen, radioactive iodine, androgens, etc.