In “Differences between rheumatoid arthritis and osteoarthritis”, some of the main differences between the two diseases are listed, from symptoms and signs to laboratory and imaging, which are relatively academic. In fact, in the early stages of rheumatoid arthritis or osteoarthritis, the clinical manifestations are often atypical and can be easily confused with each other. In particular, female patients are nervous when they have peripheral joint pain, swelling of the hands, and morning stiffness around menopause, thinking they have rheumatoid arthritis. According to my clinical experience, the two diseases can be easily differentiated according to the following points. This is also more important: 1, early diagnosis or warning of rheumatoid, not to miss the best period of treatment; 2, to avoid the fear of osteoarthritis patients suffering from rheumatoid to panic; 3, and even to reduce the cost of biochemical tests, immunological tests and imaging tests to exclude rheumatoid arthritis, as well as to patients due to the side effects of imaging tests. RA and OA early differentiation points signs and symptoms: rheumatoid arthritis (RA) hand joint lesions more metacarpophalangeal joints, proximal interphalangeal joints, or wrist joints, distal interphalangeal joints occasionally onset; osteoarthritis (OA) more than 90% occurred in the distal interphalangeal joints. In rheumatoid arthritis (RA), even in the early stages of the disease, there is more swelling of the proximal interphalangeal joints and local skin darkening of the joints; in osteoarthritis (OA), the joints are usually not swollen and the skin color is normal. In rheumatoid arthritis (RA), morning stiffness lasts for more than an hour or even the whole day; in osteoarthritis (OA), it is mostly within half an hour or less. The degree of stiffness is mild, with only a feeling of swelling. Poor grip strength in rheumatoid arthritis (RA); normal in osteoarthritis (OA). Most patients with rheumatoid arthritis (RA) have general discomfort such as weakness, or with increased body temperature, or they feel localized heat in the joints; osteoarthritis (OA) generally has no general symptoms. Menopausal syndrome symptoms specific to menopausal women include baking heat and sweating, and irritability of the five hearts.