Natriuretic heparin calcium injection is an anticoagulant, so side effects are commonly bleeding at different sites, especially in patients who also have a combination of other risk factors. There may also be an increase in transaminases, which is usually transient. Small edema at the injection site may occur, and in some cases, hard nodules may be seen, which are not heparin-induced capsules and which usually disappear after a few days, as well as injection site reactions. Platelet counts should be monitored throughout the use of natriuretic heparin calcium to prevent bleeding due to low platelets. Concomitant use of medications that pose a risk of bleeding, such as acetylsalicylic acid, nonsteroidal anti-inflammatory drugs, and ticlopidine, as well as glucocorticoids and patients receiving oral anticoagulants, are not recommended and may pose a risk of bleeding.