Waking up from sleep with dry mouth and toothache may be due to Schergren’s syndrome. Sjögren’s syndrome causes dry mouth due to destruction of the salivary glands, which leads to violent caries, which progresses to pulpitis causing tooth pain, as described below. Sjögren’s syndrome is an autoimmune disease characterized by progressive destruction of the exocrine glands, including atrophy of salivary gland follicular cells, and decreased salivary secretion, leading to dry mouth. Due to the loss of the cleaning and buffering effect of saliva, caries is very easy to occur, and often violent caries, caries deep into the pulp when the development of pulpitis, tooth pain symptoms. If the above symptoms occur, it is recommended to go to the hospital in time, with the help of the doctor for targeted treatment.