Thyroid grade 5 generally refers to thyroid nodule grade 5, which is a kind of grading under thyroid ultrasound, the malignancy rate of thyroid nodule grade 5>90%, which is generally more serious. Thyroid nodules are nodules that occur in the thyroid gland, there are benign and malignant, the most common benign is thyroid adenoma, the most common malignant is thyroid cancer. The malignant rate of grade 5 thyroid nodule is more than 90%, which is more serious, and should go to the hospital in time for pathological puncture examination to confirm whether it is a malignant tumor through pathological diagnosis. If it is malignant tumor, timely surgery is needed. Patients may be overly worried about their condition in daily life and are prone to fear, anxiety and restlessness. Family members should give comfort to the patient in time and help to channel the bad emotions, so that the patient can maintain a positive and optimistic mindset, build up confidence and actively cooperate with the doctor for treatment. Thyroid nodule grade 5 patients should be timely under the guidance of the doctor to carry out regular treatment, so as not to delay the condition.