Indications for the treatment of chronic lymphocytic leukemia include progressive bone marrow failure, obvious symptoms related to the disease, huge spleen, patient’s will, progressive lymphocytosis, and enlarged giant lymph nodes, etc. Treatment can be started as long as any of these indications are met. 1. Progressive bone marrow failure: As the development of chronic lymphocytic leukemia leads to the invasion of bone marrow, patients should receive treatment as soon as progressive bone marrow failure occurs, otherwise the severe bleeding, anemia and infection caused by bone marrow failure may lead to death. 2. Obvious disease-related symptoms: Patients should also receive timely treatment if they develop obvious symptoms such as severe fatigue, non-infectious fever, sweating and weight loss. 3. Huge spleen: many patients will have different degrees of splenomegaly, which is one of the indications for the treatment of the disease. 4. Patient’s wish: the patient himself wants to receive standardized treatment. 5. Progressive lymphocytosis: the occurrence of the disease itself will lead to abnormal values of lymphocytes in the patient’s body, so when progressive lymphocytosis occurs, it is also necessary to pay attention to timely treatment. 6. Giant lymph node enlargement: Enlarged lymph nodes with a diameter of more than 10cm should also be treated promptly. If the treatment indications are met, the patient should actively cooperate with the doctor to carry out the treatment, the drugs include phenylbutyrate nitrogen mustard, ibrutinib and so on, in order to slow down the progress of the disease and improve the survival time of the individual.