Theoretically, the probability of adverse reactions increases when polio and DPT vaccines are administered at the same site at the same time. Polio vaccine is an inactivated viral vaccine and DPT vaccine is an attenuated mixed vaccine made of multiple viral toxins. The two vaccines belong to different types of vaccines, and theoretically, simultaneous vaccination will increase the risk of adverse reactions, but at present there is a lack of authoritative clinical literature to clarify this situation. However, there is a lack of authoritative clinical literature on this situation. In clinical practice, the two vaccines are usually administered at different sites or at different times to minimize the occurrence of adverse reactions. If symptoms such as rash, skin redness and swelling, fever, and rapid breathing occur after vaccination, it is recommended to go to the hospital in time. Vaccination is an important measure to prevent diseases, and it is recommended that people who meet the conditions for vaccination should receive vaccination in time; vaccination advice is recommended to professional medical institutions, and a certain period of hospital observation is required after vaccination.