In general, persistent abdominal pain ten days after duodenal perforation may be due to inflammatory mediators or intestinal obstruction produced by surgery or intestinal contents. Clinically, after duodenal perforation, the intestinal contents enter the abdominal cavity, which in turn leads to diffuse peritonitis in the patient, which manifests itself as severe abdominal pain, tenderness, rebound tenderness, and abdominal muscle tension. In the duodenal perforation repair surgery will be carried out at the same time as the abdominal cavity irrigation, if the inflow of intestinal contents into the abdominal cavity is not rinsed out, it will continue to stimulate, which will lead to postoperative persistent abdominal pain. Rough handling during surgery can also damage the abdominal wall or abdominal organs, causing persistent postoperative abdominal pain. Adhesive bowel obstruction may also occur after surgery, resulting in persistent abdominal pain with vomiting, abdominal distension, and cessation of bowel movement. When these symptoms occur, it is recommended to inform the doctor in charge of the case, complete the examination, clarify the condition, and follow the doctor’s instructions to treat accordingly.