High glutamate may be caused by physiologic reasons, or it may mean that you have liver or pancreatic disease, or it may be caused by medication. 1. Physiologic causes: If glutamate is only mildly elevated, it may just be a transient elevation caused by staying up late and drinking a lot of alcohol. 2. Pathologic causes. (1) Liver disease: high glutamate indicates that the liver may be damaged, for example, with alcoholic liver disease, fatty liver, primary sclerosing cholangitis, etc. (2) Pancreatic diseases: chronic pancreatitis, pancreatic cancer and other diseases can also cause elevated glutamate. (3) Drug factors: If you take salicylic acid preparations, cephalosporin antibiotics and other drugs for a long time, it will also cause some damage to the liver, which will lead to elevated glutamate. If the examination found that glutamate is high, you need to improve other liver function tests, to clarify the specific disease, and then targeted treatment.