Patients with retinoblastoma are treated with surgery to remove the eye, but are not always cured. Retinoblastoma is one of the most common malignant tumors in pediatric ophthalmology, usually developing within two years of age, and can lead to discomfort such as loss of vision, elevated intraocular pressure, and even white pupil syndrome. If the patient’s condition continues to progress and the tumor infiltrates into the orbital tissues, it is difficult to cure the disease even with surgical removal of the eyeball, and radiation therapy and other treatments are usually needed to improve the survival rate. The key to retinoblastoma treatment is early detection, so newborn screening is essential to improve healing if the tumor can be detected and treated in the early stages of formation.