Rheumatoid arthritis taking hormones generally need about 3 months, serious patients need to extend the course of treatment appropriately. But in the process of taking hormones need to gradually reduce the amount, and timely observation of the long period of hormone adverse reactions such as femoral head necrosis and osteoporosis, etc., found that the problem of timely discontinuation of the drug. When anti-rheumatic immunosuppressants such as methotrexate and leflunomide are not yet fully effective, hormones are needed to alleviate the patient’s pain symptoms. This is because anti-rheumatic immunosuppressants take a long time to take effect, with some drugs taking up to 3 months to take full effect, and often needing to be continued for a longer period of time thereafter. Once the anti-rheumatic immunosuppressants have taken full effect, the dosage of hormones should be continuously reduced. Prolonged use of hormones carries the risk of inducing diseases such as diabetes, osteoporosis, various infections, or necrosis of the femoral head, requiring further adjustment of current medications while gradually reducing the dosage of hormones. If any intolerable discomfort occurs after taking hormones for rheumatoid arthritis, the medication needs to be stopped and the dosage cycle reduced. All of the above medications should be used in accordance with the doctor’s instructions, and patients with rheumatoid arthritis are advised to consult a rheumatologist promptly.