Patients with toe pain may be due to the presence of extrusion, infection, vascular lesions and other factors, as follows: First, extrusion factors: some patients due to long-term extrusion, followed by pain, such as patients wearing very crowded shoes for a long time, and standing for a long time, will make the tip of the foot area of excessive pressure, ischemia will occur, followed by symptoms of pain. Second, the infection factor: some patients have pain due to infection here, such as when patients cut nails, cut too short and cause foot inguinitis, it is very easy to lead to toe pain. Third, vascular lesions: some patients may be due to vascular lesions and lead to pain, such as diabetic patients with long-term blood sugar control is not good, often prone to vascular lesions in the foot, so that the tip of the foot ischemia, necrosis, and then appear pain.