Itchy skin all over the body can be caused by high blood sugar, there is no “which two itchy places may be high blood sugar”. It is recommended to go to the hospital for further examination when itching occurs without any obvious cause to clarify the cause of the disease. High blood sugar can be further caused by increased urinary glucose, increased urine osmolality, increased urine output; long-term increased urine output may lead to excessive dryness and itching of the patient’s skin. Therefore, itchy skin all over the body may be a hint of high blood sugar. These are the reasons why diabetics often suffer from itchy skin. Female diabetic patients also due to high blood sugar, immunity decline, vulvar skin is often contaminated by sugar-containing urine, bacteria, fungi also “take advantage of the fire”, may cause vulvovaginitis. Therefore, itchy skin all over the body may be related to elevated blood sugar. For patients with itchy skin, they should consult a doctor as soon as possible to avoid delays.