Spindle cell carcinoma is mainly composed of spindle cells and can occur in any organs or tissues, such as stomach, lungs, etc. If it is found in early stage, it should be handled as early as possible and reviewed regularly; if metastasis has occurred, it may recur and metastasize even after resection. Spindle cell carcinoma can occur in epithelial tissues or in mesenchymal tissues, and common sites include gastrointestinal tract, esophagus, bladder and uterus. If the cancer is early stage and has not metastasized at the time of examination, after timely surgical resection, the result is usually good and may achieve a cure, but regular review is needed. If metastasis has occurred, even though the primary focus is removed, the treatment effect is mostly unsatisfactory, and it is necessary to cooperate with other adjuvant treatments such as radiotherapy and chemotherapy. Once found, spindle cell carcinoma needs to be resected and pathologic immunohistochemistry should be perfected in order to formulate the next treatment plan.