Acyclovir gel and cream have the same efficacy, only the dosage form is different, there is no comparison, please follow the doctor’s instructions to use. Acyclovir gel is mostly used for herpes simplex or herpes zoster infections. Patients need to wear finger cots or rubberized leather gloves when applying Acyclovir Gel to avoid infecting other areas. It is used with caution in pregnant and nursing women and is limited to rubbing on the skin. It should not be used by people who are allergic to acyclovir. Acyclovir cream is also indicated for herpes simplex or herpes zoster infections. Possible adverse reactions include mild pain, burning, tingling, itching, and rashes; if an adverse reaction occurs, the medication should be discontinued and the topical medication should be washed off again. If symptoms are not relieved after seven days of continuous use of acyclovir cream, you should ask your doctor. When using acyclovir gel and cream, patients are advised that they should follow their doctor’s instructions for medication.