Chemotherapy has some side effects, but they do not show up right after the first dose. They usually appear slowly during the second or third dose because chemotherapy drugs tend to have a “cumulative effect”. Here are some questions about chemotherapy side effects frequently asked by patients, which are answered here in the hope of helping patients. Gastrointestinal symptoms – The main side effects of chemotherapy for liver cancer are nausea, vomiting, loss of appetite during chemotherapy, and even diarrhea in more serious patients, who may be more sensitive to chemotherapy drugs. These patients may be more sensitive to chemotherapy drugs. This gastrointestinal adverse reaction will often be slowly relieved 3~5 days after the drug is administered, if the patient vomits more violently, some anti-emetic drugs can be used after consulting the doctor, if the diarrhea is more serious, some anti-diarrheal drugs can also be used. Some patients may become constipated and can use some laxatives. Bleeding – if it is subcutaneous bleeding, the first thing to consider is that the patient has coagulation dysfunction and needs to check liver function to see if the ability to synthesize coagulation factors is normal; if it is blood in the stool, the patient needs to consider if he has a peptic ulcer, inflammation or even a tumor and needs to do some related tests; if it is massive bleeding from the digestive tract or even vomiting blood, this may be caused by chemotherapy aggravating the patient’s own disease (chemotherapy will have an impact on liver function, and cirrhotic esophageal varices may rupture and bleed), and once this happens, the patient needs to be sent to the hospital immediately for treatment. For patients at risk of this, prophylactic medication (such as acid suppressants, consult your doctor for details) is needed before or during chemotherapy. Infection – This is one of the more serious side effects of chemotherapy. Because chemotherapy has a suppressive effect on the patient’s bone marrow, it can lead to a lower white blood cell count and a lowered immune system. If the white blood cells are lowered by laboratory tests, the doctor needs to be consulted and may have to give a leuke-raising injection. For low immunity, immunity-boosting drugs can be used appropriately (not necessary, but there is no harm in using them). If the patient’s immune system is low due to malnutrition, it is necessary to improve the diet. Some patients think that if they eat more, the normal cells will grow well and the cancer cells will grow together, but in fact, it is not true. The harm level of cancer cells after surgery is very low, and eating some highly nutritious food has basically no effect on cancer cells. Therefore, in the early stage after surgery, patients should still make up their nutritional status, and if they recover quickly, they can just resume normal diet after a period of time. Molting of hands and feet – Patients with hepatocellular carcinoma seldom have molting of hands and feet with chemotherapy, but this phenomenon is more common when using targeted drugs. I suggest patients to apply some vitamin E cream on the molting area and try not to tear off the skin by themselves. Joint redness and swelling – Only a very small number of patients respond to chemotherapy with joint redness and swelling, and this has very little to do with the side effects of chemotherapy. If a patient has symptoms related to this, it may be an immune system disorder and needs to be checked by the immunology department.