After the operation of atrial septal defect, it is necessary to take antiplatelet drugs (aspirin) on time, avoid strenuous cough and exercise, and prevent infection. 1. The blocker of the left atrium is easy to form thrombus on the surface, which can cause systemic thromboembolism. After surgery, it is necessary to apply antiplatelet drugs, such as aspirin and clopidogrel, etc., according to the doctor’s prescription, which can reduce thromboembolism complications and so on. 2. Atrial septal defect is prone to arrhythmia due to congenital developmental abnormality and adverse effect on the heart caused by changes in blood flow dynamics. Therefore, two months after the operation, we should pay attention to avoid strenuous cough and exercise to reduce the stimulation of the blocker to the surrounding tissues. 3. Because of the susceptibility to infective endocarditis after atrial septal defect surgery, it is also very important to prevent infection. Specifically, you should follow your doctor’s instructions and go to the hospital as soon as possible if you feel unwell.