After vaccination with 13-valent pneumonia vaccine, babies may have systemic adverse reactions such as fever, malaise and localized adverse reactions such as nodules and pain at the vaccination site. Adverse reactions induced by 13-valent pneumonia vaccine are generally not characterized by specificity, and are similar to those of other vaccinations, mainly including systemic and local adverse reactions. Common systemic adverse reactions are fever, malaise, diarrhea, crying, coughing, nausea, vomiting, drowsiness, metrorrhagia, muscle pain, etc. Local adverse reactions include redness, swelling, pain, itching, and hardness at the site of vaccination to varying degrees. Usually, babies do not have any discomfort after receiving 13-valent pneumonia vaccine, or have mild systemic or localized reactions, which can be gradually relieved. If your baby’s symptoms are severe, it is recommended that you seek prompt medical attention.