Progesterone will cause discomfort to the body if used for a long period of time and may cause gastrointestinal reactions, endocrine disorders, and decreased menstrual flow. 1. Gastrointestinal reaction: long-term use of progesterone may lead to nausea and vomiting. 2. Endocrine disorders: the use of progesterone for too long a period of time, there may be endocrine disorders side effects, the imbalance of estrogen levels in the body, breakthrough bleeding, changes in the nature of secretions, affecting life. 3. Progesterone belongs to the progesterone class of drugs, mainly to replenish the body’s progesterone, generally used in pregnancy to protect the fetus, menstrual irregularities used to regulate the menstrual cycle, if the long-term use of large quantities, can change the menstrual cycle, menstrual abortions or bleeding between menstruation. Long-term use of progesterone is not recommended and will have an impact on the body. If a situation arises during the use of progesterone, you should seek medical attention in a timely manner.