Blood creatinine 600μmol/L suggests that the patient is suffering from renal failure, which can be further categorized into chronic and acute renal failure. Commonly used treatments include hemodialysis, peritoneal dialysis and other renal replacement therapies, but other targeted treatments should be done in conjunction with the patient’s condition, and the prognosis of different diseases is also different. For patients with chronic renal failure, doctors will promptly correct the patient’s acidosis, electrolyte disorders, hypertension, hypocalcemia, infection and other complications. Dialysis is used to protect kidney function in case of high creatinine. If a suitable kidney source can be found, kidney transplantation can also be performed if the economic conditions allow. If the patient is in acute renal failure, firstly need to stop the drugs of renal injury, and choose glucocorticoid to manage, and at the same time, combined with renal replacement therapy, most of the patients’ renal function can be restored. In conclusion, once the patient has creatinine 600μmol/L, he should go to the hospital in time and follow the doctor’s instructions to avoid further kidney damage.