Numbness of the hands and feet after waking up hungry in the middle of the night may be caused by diabetic neuropathy, hypoglycemia and other diseases. 1. Diabetic neuropathy: diabetes causes a wide range of neuropathy, resulting in autonomic neuropathy, cerebral neuropathy, localized limb neuropathy, peripheral neuropathy, etc., can appear distal symmetric sensory-motor abnormalities, such as numbness of the distal limbs of the limbs, coldness, insect crawling, or a feeling like electrocution. 2. Hypoglycemia: Insufficient sugar intake and insufficient production will lead to hypoglycemia. Hypoglycemia attack will show autonomic hypoglycemia symptoms and cerebral neuron hypoglycemia symptoms, and there will be hunger and sensory abnormalities. There are many possible causes of numbness in the hands and feet after waking up in the middle of the night after hunger, you should consult a doctor in a timely manner to identify the cause of the disease for treatment, do not delay the condition.