Habitual abortion refers to three or more consecutive spontaneous abortions with the same sexual partner and is a clinically difficult to treat infertility. About 15-20% of these pregnancies are clinically confirmed spontaneous abortions and 1-3% are recurrent abortions. About 3-8% of couples with habitual miscarriage have chromosomal abnormalities, including: translocations (44%), chimerism (48%), deletions or inversions (8%). Among them, balanced translocation carriers are more common. Both spouses have an equal chance of having the disease. The presence of these chromosomal abnormalities can lead to clinical infertility, miscarriage and stillbirth, and a history of malformations. In a Japanese study of 1284 RSA couples, 34 males were found to have chromosomal translocations. The clinical incidence of miscarriage was 61.1% in males carrying reciprocal translocations, 36.4% in males carrying Robertson translocations, and 28-42.9% in males with chromosomal inversion abnormalities. The common chromosomal abnormalities are chromosomes 13, 18, 21 and Y. About 50% of these chromosomal abnormalities are found in miscarriage products, mainly including chromosome trisomies, X chromosome monosomes, triploidy, structural abnormalities and tetraploidy. Aneuploidy abnormalities can occur in almost all chromosomes and account for more than 70% of chromosomal abnormalities associated with spontaneous miscarriage. All normal individuals have 23 pairs of chromosomes, one from the maternal side and one from the paternal side. Chromosomes control the growth and development of our entire body and are the core and middle force of the body, like a command in society, issuing orders to other bodies. Twenty-two of these pairs of autosomes control general traits, and one pair of sex chromosomes controls our sexual organs and fertility The male sex chromosome is XY. Abnormalities in either autosomes or sex chromosomes, such as abnormalities in number and structure, can affect our fertility, and some of us, despite appearing relatively normal on the outside, with fairly normal appearance and intelligence, have certain Some of us, despite appearing to be relatively normal in appearance and intelligence, can have certain chromosomes that are abnormal and are called “carriers”, a group of people that should not be underestimated. Although such individuals are difficult to detect in the population, they may pass the abnormal chromosomes down the family line from generation to generation. Problems with the gestational egg and embryo are the main causes of early miscarriage and can be broadly classified as genetic abnormalities (abnormalities of chromosomes, genes, etc.), reproductive system infections (infections with Toxoplasma gondii, cytomegalovirus, rubella virus, herpes simplex virus, etc.), endocrine disorders (luteal insufficiency, hypothyroidism, etc.), abnormal development of reproductive organs (abnormal development of the uterus or cervix, uterine adhesions, uterine fibroids), and immune abnormalities (anti-sperm antibodies, anti-ovarian antibodies, anti-endometrial antibodies, anti-cardiolipin antibodies, endometrial tolerance to embryos) are all related to habitual abortion. The above tests have been used as routine tests in our fertility center. Among male infertility patients, chromosomal abnormalities are 2%-8% (5% on average) and 10 times more common than in the general population. In couples with RSA of unknown origin, the results showed that a higher percentage of males in this RSA population (about 82%) carried a Y chromosome microdeletion than in the control group . In addition when the paternal partner is older than 40 years, there is a steady and increasing rate of miscarriage with age, especially when the maternal partner is 35 years old or older, which is more pronounced in today’s society where late marriage and late childbearing are common, leading to an increase in the habitual miscarriage population. For patients with chromosomal abnormalities, such as balanced translocations, PGD (preimplantation genetic diagnosis) or prenatal karyotype testing (amniocentesis) or even donor insemination may be recommended. In addition, women who have suffered spontaneous miscarriage are reminded to go to a regular hospital for systematic examination in addition. Although they are willing to actively go to the hospital to receive fertility treatment, they often receive fertility treatment only after signs of miscarriage such as abdominal pain and bleeding have occurred, at which time most of the effects of fertility treatment have already suffered a discount. It is important to remember that the treatment should be “early” and “effective”. As soon as you find out that you may be pregnant, you should go to the hospital for necessary tests, such as measuring serum estradiol, HCG and progesterone levels, and choosing the type and dosage of medication you need depending on the hormone you are deficient in.