The typical clinical manifestation of primary dry syndrome is dry mouth and dry eyes. However, many patients, especially young women, have no obvious symptoms at the early stage of the disease, and at the same time, part of the elderly women do not recognize that dry mouth and dry eyes are also a disease. Therefore, how to detect primary dry syndrome at an early stage has become a concern for doctors and patients. What conditions should be considered primary dry syndrome? 1. Rapid appearance of dental caries or tooth loss in recent months or years; 2. Recurrent parotid enlargement in adults; 3. Atypical arthralgia, especially in elderly women, which does not meet the diagnostic criteria of rheumatoid arthritis; 4. Recurrent purulent infection of eyelids; 5. Acidosis of distal renal tubules and hypokalemic flaccidity; 6. Unexplained hyperglobulinemia; 7. Unexplained interstitial lung fibrosis; 8. Unexplained Hepatobiliary duct damage; 9, chronic pancreatitis.