Blocking the cerebral nerve, crestal nerve and its ganglion, or sympathetic ganglion with local anesthetics, etc. to achieve the purpose of relieving pain, improving blood circulation, and treating painful diseases through nerve block is called nerve block therapy. Although the operation method of nerve block therapy is basically the same as that of nerve block, the purpose of nerve block therapy is different, so the drugs used and their concentration may also be different, and the position adopted during the operation is also different. The mechanism of action of nerve block therapy is as follows: (1) blocking the nerve conduction pathway of pain; (2) blocking the vicious cycle of pain: clinically, it is observed that the analgesic time produced by applying local anesthetic nerve block significantly exceeds the anesthetic action time of local anesthetic itself; some patients with pain lasting for several years, when multiple methods of treatment are ineffective, can be relieved of pain with only one nerve block treatment, which shows that the application of local anesthetic for pain treatment can be used to block the pain. This suggests that blocking local nerve conduction pathways is not the only mechanism of action when local anesthetics are used to treat pain. It is generally believed that this is due to the fact that nerve block therapy cuts off the vicious circle of “pain® muscle tension or small vessel smooth muscle spasm® pain increase”. (3) Improvement of blood circulation: Sympathetic nerve block improves blood flow to the innervated area, thus effectively improving pain caused by poor peripheral blood circulation. (4) Anti-inflammatory effect: Studies have confirmed that nerve block therapy, especially sympathetic block therapy, has an anti-inflammatory effect and consequently produces good analgesic effects.