The Omicron variant strain is one of the mutated strains of the Neocoronavirus, which is more contagious and usually causes milder symptoms. The Omicron variant strain refers to the B.1.1.529 variant of the Neocoronavirus, and is the result of upwards of 30 mutations in the gene for the bursting protein. Some of the mutations cause some changes in transmission, virulence, and immune escape. Some of the mutations in the bursting protein, including mutations at sites that enhance viral replication as well as receptor affinity, have led to a more infectious Omicronjon that is stronger than the mutant strains that appeared previously, such as Beta and Delta. At the same time the virulence of the virus was reduced and infections were predominantly mild and asymptomatic. The omicron variant strain also has multiple mutations in the S protein, including E484A, K417N, and N501Y, and is more immune evasive. Some of the mutations also reduce the neutralizing activity of the antibody drug, making the vaccine less protective. In light of the current outbreak situation, individuals are advised to actively comply with local outbreak prevention and control measures, wear masks when out and about, maintain a social distance, and refrain from cross-city and cross-province work and travel unless necessary.