I think you have already had a preliminary impression of the amazing effects of fat grafting: fat grafting is mainly dedicated to solving facial depressions caused by loss of volume; once the grafted fat survives, it will be able to obtain a permanent improvement in volume; and because the grafted fat is autologous, it is of course a good choice for those who are afraid of temporary, exogenous fillers. While the above is what we call traditional fat grafting, modern science has revolutionized the concepts and techniques of fat grafting. It has been proven that the final results of fat grafting are mainly achieved through the regeneration of fat stem cells in the adipose tissue. Fat stem cells are so versatile that while they do their job of ensuring the survival of fat grafts, they also have another important part-time job – to improve skin quality. Regarding the concept of fat stem cells, the editors have been many times to amenable, will not repeat here, summarized into four words, that is: the more the better. How to increase the content of stem cells to improve the clinical effect of fat transplantation? A small sip of restless specialists (ke) expert (xue) teaching (guai) teaching (ren) on the continuous research and refinement, try to do stem cells “the more the better”, has gradually developed into a relatively standardized operating procedures. There are a number of critical steps, such as the gradual processing of adipose tissue obtained through liposuction, including centrifugation, de-watering, digestion, re-centrifugation, etc. The sole purpose of these procedures is to try to increase the number of stem cells in the adipose tissue and thus ensure the retention of volume in the long term after transplantation. However, as a plastic surgeon, we are faced with a wide variety of needs from different candidates on a daily basis. In addition to volume replenishment, our patients often make other requests. For example, dark circles and fine lines around the eyes and neck. We know that collagen loss and thinning of the dermis is the main cause of dark circles and fine lines around the eyes, which can be solved by stimulating dermal regeneration with various growth factors secreted by stem cells. The question arises, how to deliver the fat stem cells to the dermis accurately? Traditional granular fat grafting seems to lack such a solution. Uneasy experts (ke) experts (xue) teach (guai) taught (ren) and came up with a new strategy: the use of physical crushing method of liposuction fat tissue processing, will be large particles of fat cells selective destruction, to retain the tissue of the tiny fat stem cells, after the treatment of the fat tissue to lose the original large particles of the solid nature of the transformation of the liquid form containing stem cells. The “liquid fat” obtained by this physical fragmentation method has a lofty name – Nanofat. The biggest advantage of this is that it can be injected precisely into the dermis layer of the skin through a tiny needle, and through the epidermal growth factor, endothelial cell growth factor, fibroblast growth factor and so on secreted by the stem cells, it directly acts on the local skin to regenerate the dermal collagen and achieve the therapeutic effect of facial rejuvenation. Aren’t you excited that fat grafting has finally achieved precision? Don’t worry, it’s not just that, it’s even better, the ultimate big star is still to come! Although nano-fat solves the problem of fine needle precision, it falls short of the goal of “the more the merrier” for stem cells. In order to achieve this ultimate goal, the SVF-gel was created. The SVF-gel is not a fatherly one, it was born from an accidental discovery (don’t laugh, it is said that all great discoveries are accidents). When we deal with nano-fat, using the physical method of extraction, inadvertently found that it can be contained in a large number of oil droplets to remove the oil to the fat tissue from the liquid state into a gel-like properties, the volume is greatly reduced, the concentration of stem cells has been greatly improved, not only to achieve the “the more the better,” and even to achieve the “The higher the concentration, the better. The best clinical indications for highly concentrated stem cell fat gel are: a series of problems brought about by skin cell aging and collagen loss, such as fine lines around the eyes, dark circles, fine lines around the mouth, neck lines and so on. Through fine needling, doctors can easily realize fine intradermal filling, significantly increase the concentration of stem cells in the injection area, and the gel-like character also makes the stem cells more firmly planted in the local area, and its secretion of various growth factors is more durable, so the facial skin rejuvenation effect is naturally significant. Nano-fat for dark circles Nano-fat for marionette lines around the mouth With the expansion of scientific research, fat grafting has expanded from a single volume filler to the application of stem cell therapy. Plastic surgeons can prepare autologous adipose tissue into a variety of “dosage forms” in order to maximize the use of stem cells to bring better, more stable and systematic facial rejuvenation treatments. Compared to nano-fat, high-density fat gel not only concentrates the stem cells, but also removes the oil droplets in the adipose tissue that are most likely to cause inflammatory reactions. If the adipose tissue is the soft gold of the human body, then the high-concentration stem cell fat gel can be considered as a thousand-foot gold in gold!