There are many causes of weakness and lack of spirit, common causes, mainly the following: First, phytodystrophy, mostly seen in menopausal women, is due to disorders of hormone metabolism in the body, mainly manifested as sleep disorders, mental lethargy, weakness of the limbs, etc., taking glutathione can regulate phytodystrophy to improve the symptoms. Second, fatigue syndrome, the disease is characterized by chronic fatigue as a characteristic clinical manifestation, mostly seen in patients with introverted personality, mental stress, can be accompanied by mental lethargy, weakness of the limbs, perfect body-related examination without organic lesions, through adequate rest and appropriate exercise can be improved. Third, the drug factor, insomnia in the elderly should take long-term sedative-hypnotic drugs, such as alprazolam, eszopiclone, with addictive, morning mental lethargy, will also lead to weakness, no clinical manifestations of the spirit, after stopping the symptoms can be relieved.