Severe infection of parapharyngeal space is considered to be related to bacterial infection, and the infection can be controlled and symptoms relieved by anti-infective drugs, surgical treatment and symptomatic treatment. 1. Antibiotics: severe infection of parapharyngeal space is mainly due to bacterial infection, so before the formation of abscess in early stage, a sufficient amount of antibiotics can be given according to the doctor’s instructions, such as ceftriaxone, moxifloxacin and so on. 2. Surgery: Before surgery, a full body examination should be carried out, and the surgery should be carried out under strict indications. For the serious infection of parapharyngeal space, and has been complicated by abscess, the simple use of drugs is not effective, need to cooperate with the doctor to give surgical incision and drainage of pus treatment. 3. Symptomatic treatment: patients with high fever can be given ice packs, drugs or fluids to reduce fever. Patients with swallowing pain or teeth clenching that affects eating can be given intravenous fluids to supplement nutrition. It is recommended that the patient should actively seek medical advice and follow the doctor’s instructions to standardize the use of medication and treatment after clarifying the condition.