Diffuse flushing refers to a group of symptoms characterized by flushing and edema of the skin in multiple areas of the body. There are many causes of generalized flushing, so it is important to detect them in time and treat them according to different causes. Diffuse flushing is commonly seen in erythrodermic disease, which is easier to diagnose. Erythroderma is a serious skin disease with systemic symptoms of widespread redness, swelling and flaking of the skin. Erythrodermic disease occurs before malignant tumors and is associated with various lymphomas, especially Hodgkin’s disease, but also with adenocarcinoma and lung cancer. The typical manifestation of erythrodermic disease is diffuse flushing, infiltration, swelling, and flaking of the skin all over the body, and the area of skin lesions involved reaches more than 80% of the whole skin. To prevent generalized flushing, we should prevent cold and heat preservation, strengthen nutrition, enhance care, prevent infection, prevent fatigue, closely observe the patient’s general condition and actively treat the original disease. 1, avoid drug abuse, do not use irritating drugs for patients with other skin diseases in the acute phase. 2, it is advisable to eat high-protein food, eat more fruits and vegetables, avoid alcohol and spicy stimulating food. 3, to drug allergies caused by erysipelas, the treatment process should be particularly careful in the choice of drugs to avoid cross-allergic reactions. 4, pay attention to the cleanliness of the skin and maintain a good environment, such as air circulation, regular space disinfection, clean bedding, etc., especially good care of the mouth, eyes, vulva and prevent the occurrence of bedsores.