Drugs used to lower intracranial pressure include hypertonic dehydrating agents, diuretics, and hormones. Hypertonic dehydrating agents include mannitol, glycerol fructose, albumin, and hypertonic saline, of which mannitol has the strongest and fastest effect, so it is generally preferred. Glycerol fructose and albumin also have a significant effect on reducing intracranial pressure. Hypertonic saline carries an increased risk of hypernatremia and needs to be used with discretion. Hormones can reduce vascular osmosis and stabilize cell membranes, and their use with mannitol can enhance the effect of lowering intracranial pressure. In addition, some diuretics, such as tachyphylaxis, also have a significant effect on lowering cranial pressure and can be used alternately with mannitol.