Sinus rhythm st-segment changes whether need treatment should be decided according to the situation, the existence of organic lesions need to be diagnosed and treated. 1. No organic lesions: sinus rhythm is a normal rhythm, if it is a long-term non-specific st-segment changes, no other clinical symptoms, and combined with other tests, such as echocardiography, there is no organic lesions, then there is no need for treatment. 2. Organic lesions: when the st-segment changes are characterized by depression accompanied by chest tightness and other clinical manifestations, or the st-segment arches are elevated upward, it suggests that coronary heart disease or acute infarction has occurred. Antiplatelet drugs such as aspirin, lipid-lowering drugs such as atorvastatin, sedative drugs such as morphine, thrombolytic drugs such as urokinase, or coronary intervention should be used according to the situation. The cause should be clarified in time when st changes occur to avoid delaying treatment, and all drugs should be used according to the doctor’s prescription.