Bloating and pain in the abdomen after taking Estradiol Valerate Tablets may be due to an adverse reaction caused by the oral medication, or due to other conditions such as acute appendicitis, acute salpingitis, acute pelvic inflammatory disease, and other conditions. The more common adverse reactions to oral estradiol valerate tablets include abdominal cramps or bloating, poor appetite, nausea, vomiting, ankle and foot edema, breast distention or swelling, weight gain or loss, localized pain, and excessive endometrial hyperplasia. However, it is often alleviated with continued use of the drug. Small abdominal distension and pain after oral administration of estradiol valerate tablets may also be due to other medical and surgical diseases such as acute appendicitis, acute salpingitis, acute pelvic inflammatory disease and so on. Oral medication discomfort is recommended to timely hospital consultation, early detection, early diagnosis, early treatment, if caused by adverse drug reactions, can be replaced under the guidance of gynecologists.