The normal reference value of neuron-specific enolase (NSE) is <16.3 ng/ml. if there is a mild elevation without abnormal manifestations, it will generally have no major impact, if the abnormal elevation is obvious and accompanied by symptoms, the possibility of tumor should be considered. 1. no significance: although NSE is one of the important markers of cancer cells, it cannot be used as the only indicator for tumor diagnosis, such as If NSE is slightly elevated and there are no other symptoms and signs as well as no abnormal performance in auxiliary examination, it has no special clinical significance; 2. Tumor: Since NSE has the highest activity in brain nerve cells, it is more closely related to tumor of neuroendocrine origin, if NSE is more than 10 times higher than the normal value and other accompanying symptoms, such as pleurisy, appear, at this time, it has higher reference significance for the diagnosis and differential diagnosis of tumor. The sensitivity of small cell lung cancer and neuroblastoma detection can be more than 80%, and the positive rate of neuroblastoma detection can be more than 90%, and the treatment of small cell lung cancer and neuroblastoma can be monitored. It is also seen in rhabdomyosarcoma, nephroblastoma and other diseases. Therefore, when NSE is elevated, it should be combined with the patient's medical history, clinical manifestations, other auxiliary examinations and pathological examinations to make an accurate diagnosis of the disease. If high NSE is found in daily life, it is recommended to seek medical attention in time to check the relevant classes to screen the disease and clarify the specific cause. If the diagnosis is tumor, surgery should be taken in time for treatment, and if the situation is more serious, postoperative treatment should also be combined with radiotherapy and chemotherapy to help patients control the disease and relieve symptoms.