Back pain after taking Zhi Bai Di Huang Wan may be related to wrong identification or medication. Zhi Bai Di Huang Wan is composed of Cornu Cervi Pantotrichum, Zhi Mu, Mudan Pi, Ze Xie, Poria, Yam, Radix Rehmanniae Praeparata, Huang Bai, etc., which can nourish yin and reduce the effect of fire. It is clinically useful for night sweating (abnormal sweating after going to sleep and stopping after waking up), hot flashes, dry mouth and throat, spermatorrhea, tinnitus, and short and red urine (small amount of urine with dark yellow color), etc. It has no definite adverse effects and contraindications. After taking Zhi Bai Di Huang Wan, lumbar pain may be related to the existence of kidney deficiency, kidney deficiency will have lumbar and knee pain and other manifestations; if the recent lifting of heavy objects, damage to the lumbar region, can also cause lumbar pain; traumatic injury and bumping can also lead to blood stasis and internal obstruction, there will be lumbar pain, if it is the lumbar pain caused by the medication, it is considered to be probably related to the identification of errors or medication errors. Taking Zhi Bai Di Huang Wan need professional doctor’s guidance, do not self-medication to avoid adverse consequences.