Symptoms of chordoma patients in the late stage: First, it usually produces severe headache. And this kind of severe headache can not be relieved by oral painkillers, and often need to be relieved and treated by psychotropic drugs. Secondly, because the chordoma erodes the bone, it may cause the phenomenon of cerebrospinal fluid nasal leakage, that is, it often flows out of the nose with inexplicable blood or water. Sometimes, if there is a combination of intracranial infection, yellow pus-colored fluid may flow out, which will be very serious and must be treated with anti-infection in time. Thirdly, sometimes chordoma will compress the surrounding soft tissues, resulting in choking on drinking water function, or even impaired consciousness and coma. And because often chordoma belongs to a kind of high consumptive disease, it may cause the late swallowing function not work, the body extremely thin, the whole body state extremely decline situation, often in the late prognosis is not good, must clarify the corresponding condition change, take the corresponding therapeutic measures at an early stage.