When chemotherapy is not available for advanced lung cancer, targeted drugs, immunotherapy and palliative conservative treatment can also be tried to minimize the pain and prolong the survival period. When chemotherapy is not available in advanced stage of lung cancer, it means that cancer tissues have invaded several organs and the patient’s body cannot tolerate the side effects of chemotherapy drugs. In this case, genetic test for lung cancer can be done to see if there is any gene mutation that the targeted drug can act on. If the genetic test shows that there are mutations that are targeted by the targeted drugs, the patient can choose the corresponding targeted drugs for treatment. If there is no genetic mutation in advanced lung cancer, you can also consider taking anti-angiogenic drugs such as apatinib or amlotinib. Anti-angiogenic drugs, by inhibiting the angiogenesis of tumor tissues, reduce the blood supply of tumor tissues, so as to play an anti-cancer role. These drugs can be taken with or without gene mutation, and may be less effective. Patients with advanced lung cancer can also consider immune checkpoint inhibitor therapy, such as navulizumab, pabolizumab and sindilizumab. They kill tumor cells by inhibiting their immune escape. If even the above drugs cannot be taken, then it can only be palliative conservative treatment, such as pain relief, inputting nutrient solution to maintain body nutrition, etc. Some Chinese medicines can also be taken to slow down the tumor progression and improve the quality of life. Lung cancer patients should seek medical treatment in time, follow the doctor’s instructions for examination and treatment, do not blindly use drugs, and follow the doctor’s instructions for regular follow-up, in order to prolong the survival time and improve the quality of life.