The redness of the palmar crease may be caused by external pressure, or it may be caused by other reasons such as contact dermatitis, cirrhosis of the liver, and keratosis pilaris eczema. 1. Extruded by external forces: If the small fish margins are extruded by external forces for a long time, it may lead to localized redness. This is a normal physiological phenomenon, can not be treated, the phenomenon can return to normal. 2. Contact dermatitis: contact dermatitis is mostly considered to be caused by contact with exogenous substances, the patient’s lesions will appear pimples, papules, erythema and other symptoms. If contact dermatitis occurs between the patient’s fissures, it will be manifested as localized redness. 3. Cirrhosis: Cirrhosis is caused by viral hepatitis, drug factors, immune factors and so on. Patients will have loss of appetite, nausea, abdominal distension, fatigue, emaciation, jaundice, anemia, liver palms, spider nevi and other manifestations. And when patients have liver palms, they may have redness between the big and small fishes. 4. Other: patients with palms of the small fiducial redness is also considered to be caused by keratosis pilaris eczema and so on. For the exclusion of localized redness caused by pressure on the small fissure, patients need to consult a doctor in time, and can choose the appropriate measures for treatment under the guidance of the doctor.