Syphilis usually begins to develop around 2 or 3 weeks after infection, with the appearance of a hard chancre and enlarged lymph nodes, but there is some variability in the timing of the onset of symptoms, depending on the individual’s physical condition and the number of viruses infecting the person. The course of syphilis infection can be divided into stages I, II and III, with stage I usually starting around 2 or 3 weeks after infection, and patients usually have no systemic symptoms, mainly chancre and enlarged lymph nodes. Stage 2 syphilis usually appears 3 to 4 weeks after the chancre has subsided, that is, around 9 to 12 weeks after infection, and can sometimes appear at the same time as the chancre, manifesting itself in syphilitic rashes, flat warts, as well as generalized manifestations such as muscular aches and pains, swollen joints, and fever, which can spread to the whole body. Stage III syphilis is caused by untreated or inadequate treatment of stage I and stage II syphilis. After 3 to 4 years, the earliest being 2 years and the latest 20 years, some patients may enter stage III syphilis. In this period, syphilis is less contagious, mainly manifested as permanent skin and mucous membrane damage, and can invade the patient’s bones, heart, nervous system and so on. For patients with high risk factors for syphilis, it is best to go to the hospital in a timely manner to improve the examination, so that early detection and early treatment.