There are many causes of sore ankles and wrists, mainly as follows: 1, external wind and cold, resulting in sore ankles and wrists, this condition is common in people with weak constitution, should pay attention to keep warm and avoid being cold. If you get cold for a long time, it is easy to cause osteoarthritis or rheumatoid arthritis, you need to go to the hospital to check the rheumatism series. 2, overwork, strain caused by wrist, wrist sore, this condition is common in people who are engaged in more physical labor, easy to cause tendinitis, arthritis. 3, gout caused by wrist, wrist sore, this condition may also be accompanied by redness, swelling, heat, pain and other typical inflammatory manifestations. It is necessary to go to the endocrinology department for uric acid test, abstain from high purine food, and not to drink alcohol.4, due to vitamin deficiency and the lack of calcium ions in the body, it may also lead to wrist and ankle acidity.