Stomach pain in the middle of the night does not necessarily mean that it is stomach cancer. Stomach pain can also be caused by other diseases, which need to be analyzed on a case-by-case basis. Stomach pain in the middle of the night is clinically common in duodenal bulb ulcer, which is typically characterized by night pain and fasting pain. Secondly, we need to exclude whether there is an acute attack of chronic pancreatitis, which can be manifested as upper abdominal pain, but will be often misdiagnosed as stomach pain. For patients with gastric cancer, most of them have no obvious symptoms in the early stage, and some of them may show epigastric pain which is aggravated after meals, poor appetite, anorexia, weakness and weight loss, etc. If patients have stomach pain in the middle of the night with the above symptoms, they need to be alerted. Therefore, it is recommended that if patients have stomach pain in the middle of the night, they should go to the gastroenterology department of the hospital for gastroscopy and other related examinations in time to identify the cause and take appropriate treatment. In daily life, attention should be paid to abstaining from alcohol and avoiding spicy and irritating foods.