Migraine is a common primary headache with recurrent attacks. Patients with migraine attacks should take medication immediately at the beginning of symptoms to achieve rapid relief of headache attacks. The selection of medication for migraine patients should be individualized according to the degree of headache and the concomitant symptoms of previous medication. For patients with mild to moderate headache, general analgesics such as NSAIDs and opioids (ibuprofen, diclofenac extended-release tablets, pethidine, etc.) can be used to stop the attacks. Migraine-specific drugs, such as treprostans and ergot alkaloids, may be effective for severe headache sufferers and when general analgesics are ineffective, but they are powerful vasoconstrictors that cause constriction of dilated intracranial arteries and are contraindicated in patients with hypertension and cardiovascular disease. In addition, some new anti-migraine drugs such as ticagrepam and osegepam are also effective. In addition, nausea is the most common accompanying symptom of migraine, which can be treated by intramuscular injection of antiemetic Gastrodia, and in severe cases, small doses of Endrin and Chlorpromazine. In addition, light and sound stimulation or daily activities can aggravate the headache, while quiet environment and rest can relieve the headache. Therefore, patients should avoid the stimulation of the surrounding environment and keep quiet and rest to relieve pain during migraine attacks. To sum up, patients should seek medical consultation promptly when migraine attacks occur and choose appropriate medications under the guidance of professional physicians in order to stop the headache attacks as soon as possible.