Redness, swelling and bulging in the stomach indicate possible gastritis, gastric ulcer, gastric polyp, gastric cancer, etc. Depending on the presence or absence of Helicobacter pylori infection, quadruple therapy is chosen, or acid-suppressing drugs as well as gastric mucosal protectants and surgical treatment are used. If a combination of H. pylori infection is found after examination in the hospital, anti-H. pylori treatment should be chosen as quadruple therapy under the guidance of a doctor. It includes a proton pump inhibitor, such as lansoprazole, rabeprazole, and a bismuth agent, such as colloidal bismuth pectin, and two antibiotics, such as metronidazole, amoxicillin. If there is no co-infection of Helicobacter pylori, acid-suppressing drugs such as omeprazole, rabeprazole, and gastric mucosal protectants such as bismuth potassium citrate and magnesium aluminum carbonate can be used as prescribed by the doctor. Gastric polyps and gastric cancer can also manifest as redness and swelling, polypectomy and surgical resection are recommended. There are many other causes of redness and bulging in the stomach, so it is recommended to consult a doctor as soon as possible and standardize the treatment under the doctor’s guidance.