Pain on the inner side of ankle may be caused by excessive movement of ankle, cold and other factors, or it may be caused by degenerative diseases of ankle joint, trauma and other pathologic factors. 1. Physiological factors: the deltoid ligament on the inside of the ankle is responsible for maintaining the stability of the ankle joint. If there are more ankle activities, such as running or climbing, it may cause fatigue of the deltoid ligament, which may cause pain on the inside of the ankle; in addition, many people like to wear ankle-exposing clothes, which leads to cold stimulation of the ankle, and the above mentioned symptom may also occur. 2. Pathological factors: due to ageing and decreasing hormone level in the body, the ankle joint may have degenerative lesions, resulting in osteophytes in the ankle joint, causing increased wear and tear of the ankle joint in the process of movement, which may also cause pain in the inner side of the ankle; trauma to the ankle joint may lead to ligament tear or fracture of the ankle joint, and the above mentioned symptoms may also occur. There may be other reasons for the pain on the inner side of the ankle, so it is recommended to go to the hospital in time, complete the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.