Acid reflux after cholecystectomy is mostly considered as bile reflux gastritis, which can be treated with gastrointestinal stimulant drugs, gastric mucous membrane protectant, acid suppressant and so on. The gallbladder is the organ that collects, concentrates, and secretes bile, and the bile is discharged directly into the duodenum after resection. After the bile accumulates to a certain degree, it can reflux into the stomach, causing bile reflux gastritis. Common symptoms include acid reflux, belching, stomach pain, etc. Treatment is based on medication. Gastrointestinal dynamics drugs commonly used are domperidone, cisapride, etc., which can promote gastric emptying; gastric mucosal protectants commonly used are bismuth pectin, bismuth potassium citrate, etc., which can prevent gastric mucosal damage; acid inhibitors commonly used are omeprazole, pantoprazole, etc., which can inhibit gastric acid secretion. Specific treatment is recommended to consult a doctor in a timely manner, guided by a professional doctor, and follow the doctor’s instructions for medication.