Amoxicillin can be used as an adjunctive treatment for some toothaches, but it is not effective for toothaches caused by deep caries and pulpitis. Amoxicillin belongs to the semi-synthetic penicillin class of broad-spectrum antibiotics, strong bactericidal effect, effective against bacterial infections, but the effect on the common anaerobic bacteria in oral diseases is poor, in the treatment of wisdom teeth pericoronitis, periodontal abscess and other causes of toothache, it is usually necessary to be used in combination with the anti-anaerobic drugs such as metronidazole, tinidazole and so on. Toothache has more causes, gingivitis, deep caries, pulpitis and other common causes of toothache, the use of amoxicillin can not play a significant therapeutic role, usually need to carry out stomatological treatment. If it is gingivitis, it can be cleaned by dental scaling (scaling) to reduce the inflammation after cleaning calculus and plaque; if it is caries need to be filled, and those who have already caused pulpitis should do root canal treatment. Toothache, you need to go to the dentist in time to receive targeted treatment, do not take medication without authorization. If you need to use amoxicillin, you should also follow the doctor’s instructions.