Sleeping at night with acid reflux, it is recommended to do the following treatments: first, is the treatment, the patient should first pay attention to sleep with the head of the bed elevated, elevated 15-20cm, which is relatively simple and effective. Secondly, pay attention to the lifestyle, avoid to reduce the consumption of fat, chocolate, tea, coffee and other foods, these foods will aggravate the gastroesophageal reflux. Secondly, it is medication, the first one is proton pump inhibitors, such as the frequently applied ones are omeprazole, pantoprazole, lansoprazole and so on. The second aspect of the drug, is the gastric protection drugs, such as cetirizine, cimetidine, ranitidine this kind of tidine drugs. The third one is the drugs that promote gastrointestinal dynamics, such as domperidone and mosapride. Besides, patients can also apply surgical treatment.