Low phosphorus occurs when taking entecavir because of decreased renal function, which causes abnormal phosphorus excretion, and requires regular checkups of renal function.
Entecavir is mainly indicated for conditions associated with chronic hepatitis B such as active viral replication and persistent elevation of serum alanine aminotransferase.
Hypophosphatemia is mainly caused by decreased phosphorus intake or malabsorption, excessive renal phosphorus excretion, and intracellular transfer of phosphorus.
Long-term use of entecavir can cause renal dysfunction, metabolic dysfunction (e.g. lactic acidosis), etc., especially in renal insufficiency, leading to abnormal renal phosphorus excretion, thus causing hypophosphatemia.
Therefore, if abnormal renal function is detected, it needs to be used with caution. When hypophosphatemia is mild, the symptoms are not obvious, but in severe cases, nausea, vomiting, myalgia, abdominal pain, muscle weakness, osteoporosis and other symptoms may occur.
Therefore, if a similar situation occurs, it is recommended to go to the hospital for examination and decide whether to continue taking the drug under the guidance of the doctor. If you are allergic to entecavir, you should not use the drug and should change to other drugs.