How to identify the severity of Parkinson’s disease?
Webster’s scale: It includes reduced hand movements, tonicity, posture, upper limb sway during walking, gait, tremor, face, sitting and standing, speech, and self-care. Each symptom is divided into 4 levels, namely normal (0 points), mildly abnormal (1 point), moderately abnormal (2 points), and severely abnormal (3 points). According to the requirements of each item to derive a certain score, and finally add up the scores of the ten symptoms, those who score below 10 are mild patients, those who score 11-20 are moderate patients, and those who score 21-30 are severe patients.
What type of drug is “Adaemet” and what is its role in the treatment of Parkinson’s disease?
It is a drug that inhibits the activity of catechol-oxo-methyltransferase; it inhibits the degradation of levodopa, stabilizes the blood concentration, and reduces the dosage and its side effects.
How is Asperger’s chosen?
It is mainly used in combination with compounded levodopa preparations, which can significantly relieve Parkinson’s disease. However, it is not currently available in China.
What should I pay attention to in methadopa treatment?
It should be used from small dose, the maximum dose is 0.25g 4 tablets a day. This drug should not be applied in the presence of severe liver and kidney dysfunction, heart disease, endocrine disorders, psychiatric disorders, pregnancy, etc.
Does Slegiline increase the death rate of patients with Parkinson’s disease?
It is safe to take Silegiline.
What is the role of dopamine agonists in the treatment?
1.It does not need to be transformed in the body to work, and is not affected by the continuous reduction of nigrostriatal cells in the brain, and has a protective effect on nigrostriatal cells.
2.It is absorbed in the intestinal tract and does not compete with proteins and amino acids in the process of crossing the blood-brain barrier.
3.It can reduce the production of free radicals and reduce the damage of dopamine nerve cells.
4.Ease the dysfunction of dopaminergic neurons.
5.Long half-life, high selectivity and easy to use.
What is the role of amantadine in the treatment of early Parkinson’s disease?
It has a mild anticholinergic effect, while promoting the release of dopamine in nerve endings and preventing its reuptake, which plays a role in Parkinson’s disease in relieving symptoms.
Efficacy of Antan
The drug is effective in improving tremor and less effective in relieving rigidity and bradykinesia. It is mainly used in patients with Parkinson’s disease who are mildly ill or who cannot tolerate levodopa-based agents.
What are the side effects of Antan? How to deal with them?
1. The main side effects of Antan are dry mouth, blurred eyes, constipation, difficulty in urination and, in severe cases, hallucinations and delusions.
2, Glaucoma and prostate enlargement are contraindicated.
3.Used with caution in people over 70 years old, as it can cause memory and cognitive dysfunction.
4.After side effects appear, the drug should be discontinued or the dosage should be reduced, and the side effects can disappear.
5.The above-mentioned side effects generally rarely occur in small doses.
How should I choose the long-acting formulation of DD Benadryl Controlled Release Tablets?
1.For those who have side effects such as motion fluctuations with regular tablets of Methocarbamol, they can switch to the use of benadryl controlled-release tablets.
2. The dosage of tablets should be increased by about 30% compared with the dosage of regular Methotrexate tablets.
3. Dosage: 2-4 tablets of restorative controlled-release tablets daily, with a dosing interval of 4-12 hours during the day.
4.Adjust the dosing regimen at any time according to the regular clinical evaluation.
5.This drug should not be chewed.
Application of Propynylamphetamine
1.It is neuroprotective effect and inhibition of the oxidation of dopamine by MAO-B.
2.Indications for treatment with midodrine alone are patients with early Parkinson’s disease and those younger than 65 years of age.
3. Generally 5-10mg per day, divided into 1-2 doses, taken at breakfast and lunch respectively.
The therapeutic effect of vitamin E on Parkinson’s disease
It is controversial, but vitamin E can be used as a protective treatment for Parkinson’s disease patients.
What is non-pharmacological treatment for Parkinson’s disease?
Parkinson’s patients should be given appropriate information during the course of the disease.
1. At the time of disease diagnosis, patients should be informed of the general natural course of Parkinson’s disease and treatment procedures.
2. 1-2 months after diagnosis, the patient should be informed of the prognosis of typical Parkinson’s disease and research advances regarding disease prevention and treatment.
3. 8 months after diagnosis, the patient should be informed of the possible complications of treatment, such as dose-related end-of-dose phenomena, motor impairment and mental retardation.
4. 2 years after diagnosis, participation in a regional Parkinson’s disease assistance group should be recommended, and a reasonable exercise program should be suggested.