Parkinson’s disease is caused by a decrease in dopamine neurons in the melanocortical band at the base of the midbrain, so dopamine supplementation is the primary treatment of choice for Parkinson’s disease. Since the advent of levodopa in the 1960s, drug therapy has become the primary treatment for Parkinson’s disease. The main problem with taking levodopa is nausea and vomiting, and reducing the amount of breakdown in the gastrointestinal tract became an important way to address side effects, and carbidopa was introduced in the 1970s with the aim of reducing gastrointestinal reactions. Standard and controlled-release tablets of carbidopa and levodopa (Benadryl) are currently used in clinical practice. A combination of benserazide and levodopa (Medobar) is also chosen outside the United States. Medobar and Xanax are essentially interchangeable. The treatment regimen for Xynine (carved dobutamine controlled-release tablets) is as follows: 1. For regimens not receiving levodopa: The starting dose of Xynine is 50 mg (carbidopa)-200 mg (levodopa)/tablet, divided into two doses, of which the maximum daily dose of levodopa is 600 mg, with a dosing interval of not less than 6 hours. 2.Replacement plan for levodopa alone: Stop levodopa for more than 8 hours first. For patients with mild and moderate Parkinson’s disease, start with one tablet 2-3 times/day. Depending on the condition, it can be adjusted to 2-8 tablets/day at 4-12 hour intervals. 3.Conversion between standard and controlled-release tablets (1)When the standard tablet is less than 400mg/day, the dose should be the same or increased by 20%, 2-3 times/day; (2)When the standard tablet is more than 400mg/day, the dose should be 120%-130% of the standard tablet, and the standard tablet should be combined with the controlled-release tablet at first, and then gradually replaced by the controlled-release tablet (3)When the first dose is taken in the morning, the dose of standard tablet should be increased by 20%, 2-3 times/day. Add a small dose of standard tablets (50-100mg). 4.Adjustment methods: (1)If the end of dose phenomenon appears within 1 hour before the next dose of Benadryl, increase the dose of Benadryl by 50% before the end of dose; (2)If the end of dose phenomenon appears more than 1 hour before the next dose of Benadryl, shorten the interval of dosing; (3)Night time variability: reduce the dose of Benadryl at night or in the evening; (4)Moderate to severe dose peak phenomenon: reduce the dose of Benadryl at the previous appearance, if it is not effective (4) Moderate to severe dose peak phenomenon: reduce the dose of benzos at the previous occurrence, if ineffective, then reduce the dose of benzos at the previous occurrence.