Penile subcutaneous pearl rash is mostly due to long foreskin, not pay attention to hygiene and infection, etc., most of them have no abnormal manifestations, do not need to be treated. However, when combined with infection, erythromycin ointment and other antibacterial drugs can be given as prescribed by the doctor, and 1:5000 potassium permanganate solution can be given to clean the local exudate. Because the pearl rash is benign lesions, and most of the uncomfortable symptoms, some patients have the possibility of self-healing, so it can not be treated. But for the combination of bacterial infection, you can use erythromycin ointment, mupirocin and other topical antibacterial drug treatment. For the pearl rash site there is broken, exudate more people, you can use 1:5000 potassium permanganate solution for cleaning, can play the role of anti-inflammatory sterilization, swelling and pain, can promote the healing of the affected area. It is recommended that patients seek timely medical care, improve the auxiliary examination, in order to clarify the condition, because there are different side effects and contraindications to drugs, so you need to be under the guidance of a professional physician for treatment.